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. 2023 Nov 24;27:121. doi: 10.1186/s40824-023-00461-z

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© The Author(s) 2023

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

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Fig. 9 — CINMs for PET-, SPECT- and PAI-guided PTT. A Synthetic procedures and mechanisms of BP@Cu@PEG-RGD NSs. B PET images of tumor-bearing mice treated with saline or NSs after 2 weeks. C Comparison of PET images with experimentally measured tumor volumes. Reproduced with permission [190]. Copyright 2020, Springer Nature. D Synthetic procedures of ^99mTc-M-CuS-PEG. E SPECT/CT images of tumor-bearing mice treated with ^99mTc-4T1-M-CuS-PEG or ^99mTc-CT26-M-CuS-PEG. Reproduced with permission [191]. Copyright 2021, Wiley-VCH. F Synthetic procedures and mechanisms of SCP-CS. G PAIs and corresponding signal intensity of tumor-bearing mice treated with SCP-CS and SCP at 808 nm and 1064 nm. Reproduced with permission [192]. Copyright 2021, Elsevier. H Synthetic procedures and activation mechanisms of Fe-Cu@PANI. I PAIs with different GSH concentrations. J Linear relationship between PA intensity and GSH concentration. K PAIs and (L) corresponding signal intensity of tumor-bearing mice treated with Fe-Cu@PANI. Reproduced with permission [193]. Copyright 2021, American Association for the Advancement of Science (AAAS)