Figure 3.

Evolution of glutamate, glucose, lactate, and pyruvate concentrations, as well as lactate/pyruvate and lactate/glucose ratios before the first positive scan displaying brain infarction in patients whose CMD probe was placed within an infarct. (a–f). Median (interquartile range) concentrations/ratios measured during the 84-h period preceding the first scan showing evidence of DCI with a probe located within an infarct (red) and the control group (black): glutamate (a.), glucose (b.), lactate (c.), and pyruvate (d.) concentrations; lactate/pyruvate (L/P) (e.) and lactate/glucose (L/G) (f.) ratios. The optimal cutoff values obtained were >16.7 µmol/L glutamate, <0.1 mM glucose, >6.3 mM lactate, <19 µM pyruvate, L/P ratio > 73.1, and L/G ratio > 35.2 (blue line). Insets: ROC curve analysis with maximum values of each patient. *p < 0.05, **p < 0.01, ***p < 0.001, linear regression mixed effect model with Man-Whitney post-hoc tests.