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. 2023 Nov 14;142(12):1747–1754. doi: 10.1007/s00439-023-02611-8

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© The Author(s) 2023

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Fig. 1 — Pedigree of a Sudanese family affected with Machado-Joseph disease, showing the haplotypes of 30 SNPs and 7 STRs segregating with ATXN3_(CAG)_n alleles in 3 siblings and their unaffected father. The proband is marked with an arrow. Individual F49-397 had several inconsistencies in his paternal haplotype (not shown), which were not possible to clarify further. Ages of onset (o.) and death (d.) are described next to the symbol of the respective patient. Individuals sampled for haplotype analysis are marked with a dash above the symbol; in case a neurological exam was performed, an X sign was added. Patients affected by history have hatched symbols