Table 2.

Age estimation of the Machado lineage in MJD families based on the genotyping of 7 STRs flanking the ATXN3_CAG repeat

Haplotype	No families	Mutation steps (n)	Age ± δ (years)
			ε = 0.01051	ε = 0.01222
H1: 10–20-10–18–7–19–24	47	0	3724 ± 804	3211 ± 693
H2: 10–20– 9–18–7 –19–24	7	1
H3: 10–19–10–18–7 –19–24	1	1
H4: 11–24– 9–18–7–19–24	6	1
H5: 16–21–9–18–7–19–24	1	1
H6: 16–23–9–18–7–19–24	1	3
H7: 16–25–10–18–7–19–24	9	6
H8: 17–25–10–18–7–19–24	5	7
H9: 17–26–10–18–7–19–24	1	8
H10: 17–25–10–19–7–19–24	1	8
H11: 16–19– 9 –13–7–19–26	1	4
H12: 10–20–10–18–7–15–24	2	1

δ—Standard deviation

ε—Probability of change per generation

¹Recombination rate (θ) based on the physical distance between the two most distant STRs

²Recombination rate (θ) based on the recombinant haplotypes observed in families