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. 2023 Nov 7;50(12):10219–10233. doi: 10.1007/s11033-023-08847-x

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© The Author(s) 2023

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 7 — PIO upregulated hepatic SIRT1/Notch1 signaling in TAM- received rats. PIO upregulated SIRT1mRNA (A) and decreased Notch1 mRNA (B) along with reduced HES1 level (C) in TAM-received rats. Data are mean ± SEM, n = 6. *P < 0.05, **P < 0.01, and ***P < 0.001. D PIO and SIRT1 interacted with one another multiple times, according to a molecular docking study. In addition to a hydrogen bond, these interactions also involve the residues Ile227 and Lys235. TAM tamoxifen, PIO pioglitazone, SIRT1 Sirtuin 1, HES1 hairy and enhancer of split1