Fig. 4.

In vivo uptake of [¹⁸F]FDG and [⁶⁴Cu][Cu(ATSM)] in the H2030-BrM3 BM model. a Timeline of experimental protocol. b Representative images of anatomical T2w MRI, [¹⁸F]FDG PET (1-h post-injection) and [⁶⁴Cu][Cu(ATSM)] (4-h post-injection), white arrows represent the intratumoral hemorrhage. c MRI and [⁶⁴Cu][Cu(ATSM)]PET, in the three planes (coronal, sagittal and transversal sections) acquired at D23. d Quantification of [¹⁸F]FDG, [⁶⁴Cu][Cu(ATSM)] uptake into cortical BM and striatal BM (at 1-h and 4-h post-injection, respectively). Mean ± SD, n = 12 rats for cortical BM and n = 8 rats for striatal BM for [¹⁸F]FDG; n = 13 rats for cortical BM and n = 8 rats for striatal BM for [⁶⁴Cu][Cu(ATSM)]. *p < 0.05 and **p < 0.01, one sample t-test vs theorical value of 1 and Mann–Whitney for comparison rSUV between cortical BM and striatal BM