Fig. 5.

Immunohistological studies in cortical and striatal BM for hypoxia-related proteins, copper transporters and astrogliosis (red) with Hoechst 33,342 nuclear counterstaining (blue). Representative images of pimonidazole, CA-IX, HIF-1a, HIF-2a, DMT1, CTR1 and GFAP immunostaining in BM and healthy brain tissue