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. 2023 Sep 14;119(15):2497–2507. doi: 10.1093/cvr/cvad149

Figure 2.

Figure 2

The Warburg effect in activated platelets. The Warburg effect or aerobic glycolysis involves the conversion of glucose/pyruvate to lactate in the presence of oxygen. It plays a highly significant role in platelet activation by ensuring a rapid production of ATP, regeneration of NAD+, regulation of platelet signaling, and biosynthesis of precursors such as nucleotides, lipids, and proteins. LDH, lactate dehydrogenase; NAD, nicotinamide adenine dinucleotide; NADH, nicotinamide adenine dinucleotide + hydrogen (H).