Table 1.
Disease coverage comparison. Union of top 20 disease-related pathways for each database by searching associated pathway titles and descriptions or captions. Disease names were compiled from the Comparative Toxicogenomics Database [14]. Average pathway counts among the top 20 disease matches per database are given in parentheses in column headers. The pathway count for the most represented disease per database is in bold italics
| Disease | PFOCR (649) | Reactome (7) | WikiPathways (7) | KEGG (3) |
|---|---|---|---|---|
| Breast cancer | 1954 | 20 | 6 | 3 |
| Fibrosis | 959 | 4 | 8 | 4 |
| Alzheimer | 874 | 6 | 12 | 2 |
| Colorectal cancer | 817 | 10 | 5 | 1 |
| Prostate cancer | 794 | 1 | 7 | 1 |
| Lung cancer | 792 | 7 | 7 | 5 |
| Lymphoma | 692 | 9 | 2 | 3 |
| Leukemia | 673 | 23 | 6 | 3 |
| Melanoma | 659 | 8 | 4 | 1 |
| Insulin resistance | 586 | 1 | 4 | 5 |
| Obesity | 529 | 4 | 8 | 4 |
| Ischemia | 483 | 2 | 2 | 0 |
| Parkinson | 464 | 4 | 6 | 2 |
| Pancreatic cancer | 435 | 1 | 6 | 1 |
| Tuberous sclerosis | 413 | 1 | 0 | 0 |
| Hepatitis | 397 | 4 | 3 | 5 |
| Hypertrophy | 380 | 0 | 6 | 4 |
| Arthritis | 372 | 6 | 4 | 1 |
| Hypertension | 358 | 2 | 4 | 2 |
| Glioblastoma | 343 | 8 | 2 | 1 |
| Atherosclerosis | 300 | 6 | 4 | 3 |
| SARS-CoV-2 | 265 | 3 | 18 | 1 |
| Retinoblastoma | 204 | 3 | 5 | 2 |
| Heart failure | 185 | 0 | 2 | 3 |
| Anemia | 179 | 6 | 1 | 1 |
| Diabetes mellitus | 177 | 1 | 3 | 4 |
| Schizophrenia | 146 | 4 | 2 | 0 |
| Renal cell carcinoma | 142 | 0 | 5 | 1 |
| Cardiomyopathy | 133 | 1 | 1 | 5 |
| Huntington | 121 | 1 | 3 | 2 |
| Multiple myeloma | 120 | 4 | 0 | 0 |
| Hyperplasia | 100 | 2 | 2 | 3 |
| AMLa | 96 | 6 | 1 | 1 |
| Ulcer | 67 | 1 | 0 | 3 |
| Hyperlipidemia | 33 | 0 | 6 | 0 |
| Hemophilia A | 3 | 4 | 0 | 0 |
| CDGa | 2 | 4 | 1 | 1 |
aAbbreviations: AML acute myeloid leukemia, CDG congenital disorders of glycosylation