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. Author manuscript; available in PMC: 2023 Nov 26.
Published in final edited form as: Annu Rev Pharmacol Toxicol. 2021 Sep 27;62:595–616. doi: 10.1146/annurev-pharmtox-052120-011012

Table 1.

Classification of Water Balance Disorders

A. Polyuric Disorders
1. Central a. Neurohypophyseal diabetes insipidus
b. Primary polydipsia

2. Nephrogenic Diabetes Insipidus a. X-linked nephrogenic diabetes insipidus
b. Autosomal nephrogenic diabetes insipidus
c. Acquired nephrogenic diabetes insipidus
 i) Drug induced (e.g., lithium)
 ii) Hypercalcemic
 iii) Hypokalemic
d. Osmotic diuresis (e.g., diabetes mellitus)

3. Gestational

B. Dilutional Hyponatremia

1. Syndrome of Inappropriate Antidiuresis (SIAD) a. Ectopic secretion of antidiuretic substances
b. Drug induced (e.g., chlorpropamide)
c. CNS-related (e.g., brain tumor, head trauma)
d. Pulmonary (e.g., mechanical ventilation, tumors)

2. Nephrogenic SIAD

3. Edematous States a. Congestive heart failure
b. Hepatic cirrhosis
c. Nephrotic syndrome

4. Exercise-Associated