TABLE 1.

Simulation results under Scenario 1 for the summary and comparison of quantitative statistical measures of treatment benefit

		PFS				RMDOR
N	Follow-up (months)	Median difference	RMST difference	HR	RMST ratio	RMDOR difference	RMDOR ratio
100	25	1.99	1.17	0.86	0.92	3.85	0.45
	50	2.04	2.64	0.83	0.87	5.75	0.44
	75	2.04	3.68	0.82	0.83	6.70	0.44
300	25	1.98	1.25	0.84	0.91	3.99	0.43
	50	1.98	2.80	0.81	0.85	5.99	0.41
	75	1.98	3.81	0.80	0.82	7.07	0.40
600	25	1.96	1.30	0.84	0.91	4.02	0.43
	50	1.97	2.90	0.80	0.84	6.07	0.40
	75	1.97	3.97	0.79	0.81	7.20	0.39

Note: For PFS, median difference (treatment vs. control) and RMST difference (Arm A vs. Arm B) are used as the absolute measures, while HR (Arm A vs. Arm B) and RMST ratio (Arm B vs. Arm A) are used as the relative measures. For DOR, RMDOR difference (Arm A vs. Arm B) is used as the absolute measure, while RMDOR ratio (Arm B vs. Arm A) is used as the relative measure. For HR, RMST and RMDOR, the maximum time window from each simulated dataset is used.

Abbreviations: DOR, duration of response; HR, hazard ratio; PFS, progression-free survival; RMDOR, restricted mean DOR; RMST, restricted mean survival time.