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. 2023 Dec 1;14(6):2267–2283. doi: 10.14336/AD.2023.0325-1

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Copyright: © 2023 Xie et al.

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Figure 6. — USP7 expression is decreased in the bone sections of osteoporotic mice. (A) Representative micro-CT image showing trabecular bone loss in OVX mice compared with sham-operated mice. (B) Bone total volume (BV/TV) was reduced in OVX mice. Data are presented as the mean ± SD. * P < 0.05. n=5 per group. Student’s t-test analysis was used. (C) Representative H&E staining and TRAP staining of trabecular bone in OVX mice compared with sham-operated mice. Scale bar = 100 μm. (D) The number of osteoclast/bone perimeter (N. Oc/B. Pm) was analyzed. Data are presented as the mean ± SD. **, P < 0.01. n=5 per group. Student’s t-test analysis was used. (E, F) Representative immunofluorescence staining images of TRAP-, USP7-, and TRAF6-positive cells in OVX mice compared with sham-operated mice. Scale bar = 100 μm. n=5 per group. Student’s t-test analysis was used. (G, H) Quantification of TRAP- and USP7-positive cells/bone perimeter. Data are presented as the mean ± SD. * P < 0.05. **, P < 0.01. n=5 per group. Student’s t-test analysis was used.