Figure 5.

FMT from healthy humans reversed the MPTP-induced gut dysbacteriosis. Quantification of alpha diversity of gut microbiota, including the Chao1 (A), Shannon (B), and Simpson (C) indices. Quantification of the beta diversity of the gut microbiota, including weighted UniFrac analysis (ANOSIM, R = 0.4275, P = 0.0010) (D) and PCoA analysis (weighted UniFrac, P = 0.0010) (E). Relative abundance of gut microbiota at the phylum level (F). Quantification of relative abundance at the phylum level, including Bacteroidota, Verrucomicrobioata, and Desulfobacterota (G). Relative abundance of gut microbiota at the genus level (H). Quantification of relative abundance at the genus level, including Muribaculaceae_unclassified, Akkermansia, and Desulfovibrio (I). Quantification of relative abundance at the genus level, including Lachnospiraceae_unclassified, [Eubacterium]_xylanophilum_group, and Odoribacter (J). Statistical analysis was performed using one-way ANOVA followed by Tukey test for data with normal distribution (n = 7, error bars representing mean ± SEM), except that alpha diversity index Simpson, phylum Verrucomicrobiota, genus Akkermansia, genus Desulfovibrio, and genus Odoribacter was analyzed using Kruskal-Wallis test followed by Dunn’s test due to the non-normal distributed data (n = 7, data presented as median (IQR)). Statistical significance was denoted as * P < 0.05, ** P < 0.01, *** P < 0.001, and **** P < 0.0001 (P values were adjusted with 6 tests, except for 5 tests in Verrucomicrobiota, Akkermansia, and [Eubacterium]_xylanophilum_group).