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. 2023 Nov 8;30(10-11):761–773. doi: 10.1038/s41434-023-00419-9

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© The Author(s) 2023

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 7 — a QALYs gained by treating existing and new patients with gene therapy. b Cumulative QALY gained by treating patients with gene therapy overall. c Cumulative QALY gained by treating patients with gene therapy broken out by new and existing patients. The line represents the mean and the shaded region represents the 5th and 95th percentiles of our simulation.