Fig. 2.

The cross-talk of extracellular cytokine pathway in psoriasis. A complex network links the essential cells and molecules in the pathogenesis of psoriasis. And the cross-talk is considered the core of the progress. On the one hand, the mutual promotion of adaptive and innate immune system produces several cytokines and maintain psoriatic hallmark features in both the dermis and epidermis. On the other hand, the keratinocytes facilitate the inflammatory mediators and enhance the expansion of local activation. Created with BioRender.com. Abbreviations: MCs mast cells, pDCs plasmacytoid dendritic cells, mature DCs mature dendritic cells, MCP Monocyte chemotactic protein, CCL20 Chemokine (C-C motif) ligand 20