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. 2023 Nov 27;8:437. doi: 10.1038/s41392-023-01655-6

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© The Author(s) 2023, corrected publication 2023

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 3 — The comprehensive view of intracellular transmission pathway in psoriasis. There are mainly two kinds of transduction way in the psoriatic cytokine. a, b The one relies on JAK-STAT and TYK2 pathways to regulate gene transcription. Specifically, IFN-α and IFN-β activate STAT1/STAT2 via JAK1 and TYK2, while IFN-γ signaling activates STAT1/STAT1 dimerize via JAK1 and JAK2.The signal of IL-12 activates STAT4/STAT4 dimerize, while IL-6, IL-23, IL-22 activates STAT3/STAT3 dimerize. c The other relies on the different cytoplasmic complexes assemble to activate NF-κB/MAPK pathway. The transduction of TNF-α, IL-17, IL-1, and IL-36 is mainly via this. Created with BioRender.com. Abbreviations: IRF9 interferon regulatory factor 9, ISRE interferon-sensitive response element, GAS IFN-γ-activated site, ISGs IFN-stimulated genes, Blimp1 B lymphocyte induced maturation protein 1, RORγt retinoic acid receptor-related orphan receptor gamma t, MyD88 myeloid differentiation factor 88, IRAK interleukin-1 receptor-associated kinases, AP1 activating protein-1, TRAF TNF receptor associated factor, Ub ubiquitin, LUBAC linear ubiquitin chain assembly complex, TRADD TNFR1-associated death domain protein, RIPK1 receptor-interacting serine/threonine-protein kinase 1, cIAP1 cellular inhibitor of apoptosis protein 1, TAK1 TGFβ-activated kinase 1