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. 2023 Nov 13;11:1297910. doi: 10.3389/fcell.2023.1297910

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Copyright © 2023 Katkat, Demirci, Heger, Karagulle, Papatheodorou, Brazma and Ozhan.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Generation of the zebrafish models of melanocyte regeneration and melanoma (A) Following neocuproine (NCP) treatment, caudal fins of individual zebrafish were collected for each group (control, 1 dpa = proliferative or early regeneration stage, and 7 dpa = differentiation or late regeneration stage) and used as biological replicates (no pooling). (B) The zebrafish melanoma model was generated by outcrossing the Tg(mitfa:Hsa.HRAS ^G12V ,mitfa:GFP) line with the wild-type (wt) AB zebrafish. 50% of the siblings (mitfa+/−) were used as the control group. 50% of the siblings Tg (mitfa+/−,HRAS ^G12V :GFP) were used to collect the nevi and melanoma tissues. Caudal fins were collected for each group and used as biological replicates (no pooling). dpa: days post-ablation.