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Comparison of randomized and non-randomized trials.
| Characteristic | Trial phase | ||
|---|---|---|---|
| Phase 3 (n = 18) | Phase 2 (n = 72) | Phase 1 (n = 12) | |
| Blinding (%) | 6 (33.3) | 3 (4.2) | 0 (0) |
| No. of participants, median (Range) | 276 (200–556) | 47 (14–206) | 108.5 (23–242) |
| Multicenter (%) | 15 (83.3) | 24 (33.3) | 7 (58.3) |
| Randomization (%) | 18 (100) | 18 (25.0) | 0 (0) |
| Primary outcome as safety (%) | 0 (0) | 4 (5.6) | 7 (58.3) |
| Primary outcome as OS(%) | 5 (27.8) | 2 (2.8) | 0 (0) |
Abbreviation: OS, overall survival.
