Table 2.

Expression of BTK in different white matter lesions in multiple sclerosis.

Brain lesion type	Log2FC	FDR
NAWM vs WM	0.90	0.13
Inactive vs WM	0.38	0.50
Remyelinating vs WM	0.84	0.30
Active vs WM	1.13	0.03
Chronic active vs WM	1.00	0.02

NAWM (normal-appearing white matter) n=19; WM (control white matter) n=25; Inactive lesion, n=13; Remyelinating lesion, n=6; Active lesion, n=18; chronic active lesion, n=17. The generalized linear model adjusted for library size and biological replicates (same lesion type//same sample//from same patient) and corrected for age and sex of the patients was used to define significant difference in BTK expression calculated by adjusted P value filtering using the procedure of Benjamini and Hochberg (false discovery rate, FDR) between MS brain areas and control brain areas was.