Figure 3.

RNA-seq reveals importance of ROS and xenobiotic metabolism in bilirubin uptake and conjugation

(A) Volcano plot for differentially expressed genes in mifepristone-treated organoids compared with control after treatment with bilirubin. Key genes are highlighted.

(B) Heatmap for mifepristone-treated organoids compared with control after treatment with bilirubin.

(C) GSEA plot depicting enhanced pigment metabolism in mifepristone-treated organoids.

(D) Enriched pathways in mifepristone-treated organoids.

(E) Cross comparison of ROS and xenobiotic metabolism pathway in a GSEA.

(F) Venn diagram depicting NRF2 as a key gene important for both xenobiotic and ROS metabolism.