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LILR signalling pathways. LILRA intracellular domain interacts with the dimeric FcεRIγ-chain comprised of cytoplasmic ITAM motifs. Phosphorylation of ITAM-bearing tyrosine residues by Src family kinases recruits Syk that mediates activating signalling cascades. Upon LILRB ligation, activated Lyn phosphorylates their ITIM domains, engaging phosphatases, which in turn abrogate activating signalling cascades essential for effector cell maturation and function.
