Table 2.
Efficacy outcomes.
| Variable | Patients (n = 20) |
|---|---|
| Confirmed best response, n (%) | |
| CR | 0 |
| PR | 4 (20) |
| SD | 15 (75) |
| PD | 1 (5) |
| ORR, % (95% CIa) | 20 (5.7–43.7) |
| DCR, % (95% CI) | 95 (75.1–99.9) |
| Median DoR (95% CI), months | 8.1 (1.7–10.6) |
| CBRb, % (95% CI) | 60 (36.1–80.9) |
Abbreviations: CBR, clinical benefited rate; CI, confidence interval; CR, complete response; DCR, disease control rate; DoR, duration of response; ORR, objective response rate; PD, progressive disease; PR, partial response; SD, stable disease.
a
Despite conservatism, the exact Clopper-Pearson method was used to compute binomial confidence intervals of each single rate due to the small sample size.
b
CBR was defined as PR + SD ≥ 6 months.