Figure 2.
Impact of vpr on innate immune activation
(A) Relative activation or inhibition state of the indicated pathways in uninfected rhesus macaques (n = 16) compared to animals infected with wt or Δvpr SIVmac239. Shown are mean values of Z scores obtained for all animals (±SEM). The dotted line indicates the average value obtained for uninfected animals. p values: ∗, <0.05; ∗∗, <0.01; ∗∗∗, <0.001. Individual values are shown in Figure S1D.
(B) Heat maps of wt versus Δvpr in PBMC dataset for the restriction factor gene sets. The datasets were obtained from PBMC samples collected at 2 or 24 wpi, respectively. The color scale is shown at the bottom, with lowest to highest gene expression across all animals represented by the blue to red color gradient.
(C) Correlation between the mean pathway level aggregation scores and the viral RNA loads at 2 (left) and 24 (right) wpi (see also Figure S1).