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. 2023 Oct 26;26(12):108351. doi: 10.1016/j.isci.2023.108351

Figure 6.

Figure 6

Lack of vpr increases survival rates and attenuated CD4+ T cell depletion

(A) Kaplan-Meier survival curves for the wt and Δvpr groups of SIV-infected macaques with time measured from the date of infection.

(B) Correlations between the survival time of animals infected with wt and Δvpr and the viral loads, T cell response, and neutralizing efficiency. The dashed line indicates the beginning of termination of the study and the dotted line the detection limit.

(C–E) Levels of (C) CD4+, (D) CCR5+CD4+ T cells, and (E) central memory T cells in blood of infected macaques compared to baseline (100%). The right panels show mean values (±SEM) measured for the wt (black) and Δvpr groups, and the middle and left panels show values obtained for individual animals. Asterisks indicate significant differences between the groups (∗p < 0.05; ∗∗p < 0.01; ∗∗∗p < 0.001).