REAGENT or RESOURCE	SOURCE	IDENTIFIER
Antibodies
CD3 (clone SP34-2, Alexa Fluor 700)	BD Bioscience	Cat#557943; RRID:AB_396952
CD4 (clone L200; Horizon V450)	BD Bioscience	Cat#560811; RRID:AB_2033927
CD21 (clone B-ly4, FITC)	BD Bioscience	Cat#561372; RRID:AB_10895576
CD28 (clone CD28.2, FITC)	BD Bioscience	Cat#555728; RRID:AB_396071
CD45 (clone D058-1283, Horizon V500)	BD Bioscience	Cat#561489; RRID:AB_10683313
CD95 (clone Dx2, PE-Cy7)	BD Bioscience	Cat#561636; RRID:AB_10896323
CD195 (clone 3A9, PE)	Biolegend	Cat#550632; RRID:AB_2072548
CD8 (clone RPA-T8, PerCP-Cy5.5)	Biolegend	Cat#301032; RRID:AB_893422
CD8 (clone SK1, APC-Cy7)	Biolegend	Cat#344714; RRID:AB_2044006
CD20 (clone 2H7, PE-Cy7)	Biolegend	Cat#302312; RRID:AB_314260
CD25 (clone M-A251, APC-Fire)	Biolegend	Cat#356136; RRID:AB_2616723
CD27 (clone M-T271, APC)	Biolegend	Cat#356410; RRID:AB_2561957
CD196 (clone G034E3, PE-Dazzle)	Biolegend	Cat#353430; RRID:AB_2564233
CD197 (clone G043H7, APC, Brilliant Violet 421)	Biolegend	Cat#353208; RRID:AB_11203894
HLA-DR (clone L243, APC-Cy7)	Biolegend	Cat#307618; RRID:AB_493586
Ki67 (clone Ki67, Brilliant Violet 605)	Biolegend	Cat#151215; RRID:AB_2876504
PD-1 (clone EH12.2H7, PE-Cy7)	Biolegend	Cat#329918; RRID:AB_2159324
MX1 (M143)	Pr. Kochs, Freiburg University	N/A
Peroxidase-conjugated Goat-Anti-Human-IgG	Jackson Bio-Lab	Cat#109-036-088
Goat-anti-monkey-IgA-PO	Nordic	Cat#109-036-088
Bacterial and virus strains
XL2-Blue MRF’ TM Ultracompetent cells	Agilent Technologies	Cat#200151
Chemicals, peptides, and recombinant proteins
L-Glutamine	Pan Biotech	Cat#P04-80100
Dulbecco’s Modified Eagle Medium (DMEM)	Gibco	Cat#41965039
Penicillin-Streptomycin	ThermoFisher	Cat#15140122
FCS	Gibco	Cat#10270106
SIV Gag peptides	NIBSC	Cat#EVA7066.1-16
SIV AT-2	NIBSC	Cat#ARP1018.1
SIV p27	NIBSC	Cat#EVA643.2
SIV gp130	NIBSC	Cat#100841
Critical commercial assays
IFN-γ ELISpot	Mabtech	Cat#3421M
GalScreen	Applied Bioscience	Cat#T1027
SIV Western Blot assay	ZeptoMetrix	Cat#0801500
Paxgene RNA purification kit	Qiagen	Cat#762164
QiaAmp viral RNA isolation mini kit	Qiagen	Cat#52906
TruSeq Stranded mRNA Library Prep	Illumina	Cat#20020595
Nextera XT DNA Library Preparation Kit	Illumina	Cat#FC-131-1096
RBC Lysis/Fixation Solution (10X)	Biolegend	Cat#422401
FOXP3 Fix/Perm Buffer Set	Biolegend	Cat#421403
Rhesus Macaque BLC ELISA Kit	Invitrogen	Cat#EP3RB
TaKaRa Prime-Script-One-Step-RT-PCR kit	Takara	Cat#RR014A
Deposited data
RNA-seq data	Gene Expression Omnibus (GEO) repository	Accession number GSE229310
Experimental models: Cell lines
Human: HEK293T cells	ATCC	Cat#CRL-3216 RRID: CVCL_0063
Human: TZM-bl cells	NIH AIDS Reagent Program	Cat#8129 RRID: CVCL_B478
Experimental models: Organisms/strains
Rhesus macaques	German Primate Center	N/A
Oligonucleotides
gag forward (5′-ACCCAGTACAACAAATAGGTGGTAACT-3′)	This paper	N/A
gag reverse (5′-TCAATTTTACCCAG-GCATTTAATGT-3′)	This paper	N/A
gag probe (5′-6FAM(6-carboxyfluorescein)-TGTCCACCT-GCCATTAAGCCCGAG-TAMRA(6-carboxytetramethylrhodamine-3′)	This paper	N/A
Recombinant DNA
Plasmid: pBR322_SIVmac 239	F. Kirchhoff (Ulm University)	N/A
Plasmid: pBR322_SIVmac 239 ΔVpr	F. Kirchhoff (Ulm University)	N/A
Software and algorithms
Corel DRAW 2021	Corel Corporation	https://www.coreldraw.com/
GraphPad Prism Version 10	GraphPad Software, Inc.	https://www.graphpad.com RRID: SCR_002798
Rstudio Rx64 4.1.14	Posit	https://posit.co/downloads/
Aperio image scope version 12.3.1.5011	Leica	https://aperio-imagescope.software.informer.com/12.3/
DESeq2 version 1.22.1 R	R Package	https://bioconductor.org/packages/release/bioc/html/DESeq2.html
GSEA desktop module 4.2.3	Broad Institute	https://www.gsea-msigdb.org/gsea/index.jsp
FACS DIVA software 6.1.3	BD Bioscience	N/A