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. Author manuscript; available in PMC: 2023 Nov 27.
Published in final edited form as: N Engl J Med. 2019 Nov 27;381(24):2293–2303. doi: 10.1056/NEJMoa1910993

Figure 2. Time to Viral Clearance.

Figure 2.

Panel A shows the time to the first negative result for Ebola virus (EBOV) nucleoprotein on reverse-transcriptase–polymerase-chain-reaction (RT-PCR) assay in all groups, with deaths imputed as the worst time. The dots indicate individual patients, the triangles indicate patients who were enrolled before January 2019 when the protocol was revised to add the REGN-EB3 group, and the horizontal bars indicate the group means. The black hashed bar in the remdesivir group indicates that the median time was not observed because more than 50% of patients in this group died before the first negative result. Data are not shown for one patient in the ZMapp group and one patient in the REGN-EB3 group who did not have a first negative result before day 28 but who had a negative result at days 48 and 41, respectively. Panel B shows the values for EBOV nucleoprotein as determined on RT-PCR, according to day of the trial. The symbols indicate the median, and the vertical bars indicate the interquartile range.