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. Author manuscript; available in PMC: 2023 Nov 27.
Published in final edited form as: Clin Auton Res. 2021 Oct 20;31(6):677–684. doi: 10.1007/s10286-021-00829-y

Table 2:

Autopsy findings in Shy-Drager syndrome (SDS) / Olivopontocerebellar atrophy (OPCA) / multiple system atrophy (MSA), in which orthostatic hypotension was the initial clinical manifestation.

First Author (Year) [Cit. No.] No. Brainstem Lewy bodies SNS Lewy bodies Note
Johnson (1966) [36] Case 2 0 0 OH first. Late bradykinesia, cerebellar signs. OPCA. IL column cell loss
Schwarz (1967) [64] Case 2
Case 3
No comment
No comment
No comment
No comment
OH first. SDS. OPCA
OH first. SDS
Nick (1967) [48] 1 0 0 OH first. SDS
Thapedi (1971) [74] 1 1 Hyaline eosinophilic bodies OH first. SDS. Parkinsonism. No comment on CBL/Brainstem atrophy
Bannister (1972) [6] Case 2 0 0 OH first. MSA
Evans (1972) [18] 1 0 No comment OH first. OPCA, no typical LBs
Schober (1975) [63] Case 1 0 0 OH first. Putamen shrinkage. MSA.
Petito (1978) [55] Patient 4 No comment No comment OH first. Pathology as in MSA

Abbreviations: CBL=cerebellar; Cit. No.= citation number; IL=intermediolateral column; MSA=multiple system atrophy; OH=orthostatic hypotension; OPCA=olivopontocerebellar atrophy; SDS=Shy-Drager syndrome; SNS=sympathetic nervous system.