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. 2023 Nov 27;18:80. doi: 10.1186/s13062-023-00439-w

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© The Author(s) 2023

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

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Fig. 4 — Hedgehog signaling pathway involves in RCC2-mediated prostate cancer cells. A Volcanic map showed the DEGs in RCC2 knockdown DU145 cells compared to control DU145 cells. B Top 8 signaling were selected in RCC2 knockdown DU145 cells compared to control DU145 cells based on NSE analysis. C GSEA analysis showed the Hh signaling pathway was enriched in RCC2 knockdown DU145 cells compared to control DU145 cells. D, E The protein expression of three genes (GLI1, GLI3, and SUFU) involved in the Hh signaling pathway in DU145 and PC3 cells after (D) RCC2 knockdown or (E) overexpression were detected with western blot. F The protein expression of three CSCs markers (SOX2, Nanog, and CD44) in DU145 and PC3 cells after RCC2 knockdown or overexpression were tested with western blot