Table 2.
Stratification analysis of PIWIL1 polymorphisms with EOC susceptibility
| Variables | rs10848087 G > A | Adjusted ORa | Pa | rs7957349 G > C | Adjusted ORa | Pa | rs10773771 C > T | Adjusted ORa | Pa | |||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| (cases/controls) | (95% CI) | (cases/controls) | (95% CI) | (cases/controls) | (95% CI) | |||||||
| GG/GA | AA | GG/GC | CC | CC | CT/TT | |||||||
| Age, years | ||||||||||||
| > 53 | 112/347 | 7/3 | 3.060 (0.720–13.010) | 0.1298 | 103/340 | 12/13 | 2.445 (0.832–7.186) | 0.1040 | 51/130 | 45/223 | 0.390 (0.221–0.688) | 0.0012 |
| ≤ 53 | 129/347 | 5/3 | > 999.999(< 0.001, > 999.999) | 0.9754 | 121/340 | 14/13 | 3.399 (1.387–8.326) | 0.0074 | 55/130 | 61/223 | 0.729 (0.467–1.139) | 0.1656 |
| Metastasis | ||||||||||||
| Yes | 84/347 | 6/3 | 8.919 (2.141–37.165) | 0.0027 | 78/340 | 11/13 | 3.622 (1.542–8.511) | 0.0031 | 41/130 | 39/223 | 0.529 (0.322–0.870) | 0.0121 |
| No | 140/347 | 5/3 | 4.232 (0.981–18.253) | 0.0530 | 131/340 | 14/13 | 2.752 (1.250–6.058) | 0.0119 | 59/130 | 65/223 | 0.624 (0.411–0.947) | 0.0267 |
| Clinical stage | ||||||||||||
| 1 | 55/347 | 3/3 | 7.301 (1.348–39.537) | 0.0211 | 47/340 | 11/13 | 5.870 (2.428–14.191) | < 0.0001 | 18/130 | 27/223 | 0.814 (0.427–1.552) | 0.5329 |
| 2 | 41/347 | 2/3 | 5.983 (0.962–37.200) | 0.0550 | 41/340 | 4/13 | 2.452 (0.760–7.919) | 0.1336 | 17/130 | 22/223 | 0.736 (0.376–1.441) | 0.3715 |
| 3 | 84/347 | 4/3 | 6.490 (1.403–30.022) | 0.0167 | 79/340 | 5/13 | 1.680 (0.576–4.903) | 0.3424 | 46/130 | 36/223 | 0.433 (0.264–0.709) | 0.0009 |
| 4 | 24/347 | 1/3 | 4.902 (0.490–49.086) | 0.1763 | 21/340 | 2/13 | 2.480 (0.524–11.746) | 0.2522 | 10/130 | 12/223 | 0.684 (0.286–1.634) | 0.3923 |
| Pathological grade | ||||||||||||
| low | 70/347 | 3/3 | 5.908 (1.143–30.546) | 0.0341 | 65/340 | 8/13 | 3.033 (1.200–7.664) | 0.0190 | 23/130 | 28/223 | 0.672 (0.369–1.224) | 0.1942 |
| high | 148/347 | 9/3 | 6.718 (1.770–25.493) | 0.0051 | 143/340 | 11/13 | 1.976 (0.852–4.581) | 0.1125 | 71/130 | 71/223 | 0.563 (0.378–0.839) | 0.0048 |
| Tumor number | ||||||||||||
| single | 73/347 | 3/3 | 5.443 (1.016–29.161) | 0.0479 | 70/340 | 11/13 | 4.063 (1.719–9.634) | 0.0014 | 28/130 | 30/223 | 0.586 (0.332–1.034) | 0.0652 |
| multiple | 108/347 | 4/3 | 4.602 (1.008–21.012) | 0.0488 | 94/340 | 9/13 | 2.490 (1.028–6.029) | 0.0432 | 53/130 | 49/223 | 0.520 (0.332–0.815) | 0.0043 |
| Tumor size | ||||||||||||
| > 3 cm | 63/347 | 4/3 | 6.503 (1.381–30.615) | 0.0178 | 57/340 | 7/13 | 3.019 (1.137–8.018) | 0.0266 | 26/130 | 24/223 | 0.523 (0.287–0.953) | 0.0343 |
| ≤ 3 cm | 158/347 | 7/3 | 5.523 (1.392–21.912) | 0.0151 | 146/340 | 17/13 | 3.024 (1.421–6.434) | 0.0041 | 74/130 | 67/223 | 0.503 (0.337–0.751) | 0.0008 |
| Pregnant times | ||||||||||||
| ≤ 3 | 104/347 | 7/3 | 7.386 (0.650–29.486) | 0.0046 | 96/340 | 14/13 | 3.768 (1.697–8.368) | 0.0011 | 45/130 | 49/223 | 0.609 (0.383–0.969) | 0.0363 |
| > 3 | 137/347 | 5/3 | 4.725 (1.096–20.367) | 0.0373 | 128/340 | 12/13 | 2.359 (1.039–5.354) | 0.0402 | 61/130 | 67/223 | 0.532 (0.348–0.813) | 0.0036 |
| Pausimenia | ||||||||||||
| post-menopause | 177/347 | 7/3 | 3.601 (0.861–15.066) | 0.0793 | 159/340 | 19/13 | 3.020 (1.394–6.544) | 0.0051 | 80/130 | 72/223 | 0.485 (0.323–0.728) | 0.0005 |
| pre-menopause | 64/347 | 5/3 | 6.172 (1.437–26.516) | 0.0144 | 65/340 | 7/13 | 3.163 (1.106–9.048) | 0.0317 | 26/130 | 34/223 | 0.860 (0.485–1.523) | 0.6048 |
| ER expression | ||||||||||||
| negtive/mild positive | 34/347 | 1/3 | .0792 (0.370–38.864) | 0.2617 | 32/340 | 3/13 | 2.262 (0.602–8.507) | 0.2269 | 14/130 | 12/223 | 0.455 (0.202–1.025) | 0.0575 |
| strong positive | 67/347 | 3/3 | 6.232 (1.202–32.300) | 0.0293 | 63/340 | 4/13 | 1.546 (0.484–4.936) | 0.4622 | 37/130 | 24/223 | 0.355 (0.202–0.625) | 0.0003 |
| PR expression | ||||||||||||
| negtive/mild positive | 34/347 | 1/3 | 3.526 (0.354–35.080) | 0.2823 | 32/340 | 3/13 | 2.418 (0.653–8.948) | 0.1860 | 17/130 | 14/223 | 0.466 (0.222–0.981) | 0.0443 |
| strong positive | 38/347 | 2/3 | 6.584 (1.048–41.362) | 0.0444 | 37/340 | 4/13 | 2.771 (0.857–8.961) | 0.0887 | 20/130 | 15/223 | 0.428 (0.211–0.868) | 0.0187 |
| PAX8 expression | ||||||||||||
| negtive/mild positive | 28/347 | 1/3 | 4.394 (0.435–44.426) | 0.2099 | 27/340 | 1/13 | 0.945 (0.118–7.555) | 0.9572 | 18/130 | 8/223 | 0.245 (0.103–0.583) | 0.0015 |
| strong positive | 62/347 | 3/3 | 5.885 (1.164–30.005) | 0.0330 | 62/340 | 2/13 | 0.840 (0.185–3.822) | 0.8219 | 34/130 | 26/223 | 0.427 (0.244–0.748) | 0.0029 |
| Wild p53 expression | ||||||||||||
| negtive/mild positive | 59/347 | 4/3 | 6.172 (1.773–37.671) | 0.0071 | 57/340 | 3/13 | 1.383 (0.381–5.017) | 0.6217 | 33/130 | 29/223 | 0.502 (0.291–0.868) | 0.0136 |
| strong positive | 182/347 | 8/3 | 4.717 (1.210–18.395) | 0.0255 | 167/340 | 23/13 | 3.460 (1.693–7.072) | 0.0007 | 73/130 | 77/223 | 0.603 (0.407–0.893) | 0.0116 |
| Mutant p53 expression | ||||||||||||
| Yes | 112/347 | 5/3 | 5.723 (1.326–24.700) | 0.0194 | 110/340 | 7/13 | 1.624 (0.626–4.211) | 0.3190 | 57/130 | 46/223 | 0.450 (0.287–0.706) | 0.0005 |
| No | 129/347 | 7/3 | 5.969 (1.496–23.817) | 0.0114 | 114/340 | 19/13 | 4.254 (20.19–8.963) | 0.0001 | 49/130 | 60/223 | 0.700 (0.451–1.085) | 0.1108 |
| WT1 expression | ||||||||||||
| negtive/mild positive | 34/347 | 1/3 | 3.712 (0.366–37.673) | 0.2674 | 33/340 | 3/13 | 2.320 (0.622–8.652) | 0.2102 | 20/130 | 9/223 | 0.240 (0.105–0.549) | 0.0007 |
| strong positive | 74/347 | 6/3 | 10.408 (2.511–43.135) | 0.0012 | 75/340 | 4/13 | 1.426 (0.450–4.518) | 0.5467 | 38/130 | 34/223 | 0.491 (0.293–0.825) | 0.0072 |
| P16 expression | ||||||||||||
| negtive/mild positive | 36/347 | 1/3 | 3.506 (0.346–35.542) | 0.2885 | 34/340 | 3/13 | 2.251 (0.603–8.402) | 0.2272 | 20/130 | 11/223 | 0.294 (0.135–0.641) | 0.0021 |
| strong positive | 66/347 | 7/3 | 12.751 (3.190–50.966) | 0.0003 | 64/340 | 6/13 | 2.424 (0.884–6.644) | 0.0854 | 31/130 | 29/223 | 0.530 (0.305–0.922) | 0.0247 |
| ki67 expression | ||||||||||||
| negtive/mild positive | 36/347 | 3/3 | 10.378 (1.947–55.310) | 0.0061 | 34/340 | 3/13 | 2.252 (0.606–8.375) | 0.2257 | 11/130 | 13/223 | 0.540 (0.276–1.484) | 0.2985 |
| strong positive | 81/347 | 3/3 | 4.598 (0.905–23.371) | 0.0659 | 76/340 | 9/13 | 3.126 (1.286–7.602) | 0.0119 | 43/130 | 34/223 | 0.445 (0.269–0.736) | 0.0016 |
aAdjusted for age and gender