Table 3.
Representative clinical studies of dendritic cell vaccines for cancer immunotherapy
| Clinical trials | Cancer types | DC vaccines | Phase | Status |
|---|---|---|---|---|
| NCT00006434 | Non-Hodgkin’s Lymphoma | Tumor lysate-pulsed DCs | 3 | Completed |
| NCT03905902 | Ovarian cancer, fallopian tube cancer, peritoneal carcinoma | Autologous DCs (DCVAC/OvCa) | 3 | Withdrawn |
| NCT00779402 | Prostate cancer | PAP-loaded DC vaccine (Sipuleucel-T) | 3 | Completed |
| NCT05100641 | Glioblastoma | Therapeutic autologous DC vaccine (AV-GBM-1) | 3 | Not yet recruiting |
| NCT02503150 | Colorectal cancer | Antigen-pulsed DCs | 3 | Unknown |
| NCT04277221 | Glioblastoma | Autologous DC/tumor antigen | 3 | Unknown |
| NCT00005947 | Prostate cancer | PAP-loaded DC vaccine (Sipuleucel-T) | 3 | Completed |
| NCT01759810 | Glioblastoma | Proteome-based DC vaccine | 3 | Unknown |
| NCT01782287 | Lung cancer brain metastases | Proteome-based DC vaccine | 3 | Unknown |
| NCT01983748 | Uveal melanoma | Autologous DCs loaded with autologous tumor RNA | 3 | Active, not recruiting |
| NCT04348747 | Brain metastasis from TNBC or HER2+ breast cancer | Anti-HER2/HER3 DC vaccine | 2 | Recruiting |
| NCT05127824 | Kidney cancer | Autologous alpha-DC1/TBVA vaccine | 2 | Not yet recruiting |
| NCT04912765 | Hepatocellular carcinoma or liver metastases From colorectal cancer | Neoantigen-loaded DC vaccine | 2 | Recruiting |
| NCT01876212 | Melanoma | Type I-polarized autologous DC vaccine | 2 | Completed |
| NCT02285413 | Melanoma | Mature DC loaded with mRNA encoding tumor-associated antigens gp100 and tyrosinase | 2 | Completed |
| NCT00266110 | Breast cancer | Therapeutic autologous DCs | 2 | Completed |
| NCT02362464 | Prostate cancer | Multi-epitope TARP peptide autologous DC vaccine | 2 | Completed |
| NCT01413295 | Colorectal cancer | Autologous DCs loaded with autologous tumor antigens | 2 | Completed |
| NCT04487756 | Lung cancer | Autologous DC vaccine | 1/2 | Recruiting |
| NCT02061332 | Breast cancer | HER-2 pulsed DC vaccine | 1/2 | Completed |
| NCT00087984 | Kidney cancer | RNA-loaded DC vaccine | 1/2 | Completed |
TNBC triple-negative breast cancer, DC dendritic cell, TARP T-cell receptor gamma chain alternate reading frame protein