Table 1.
Maternal baseline characteristics
| Variables | Control group (n = 48) |
rhTPO group (n = 33) |
Statistical value | P |
|---|---|---|---|---|
| Age | 30 (27.3, 32) | 29 (26, 30) | -1.352a | 0.176 |
| BMI (kg/m2) | 24.4 ± 2.3 | 24.6 ± 4.0 | -0.407b | 0.685 |
| Monthly income (CNY) | 1.077c | 0.584 | ||
| < 5000 | 13 (27.1) | 9 (27.3) | ||
| 5000–10000 | 30 (62.5) | 18 (54.5) | ||
| > 10000 | 5 (10.4) | 6 (18.2) | ||
| Number of births, n (%) | 3.057c | 0.217 | ||
| 0 | 25 (52) | 22 (67) | ||
| 1 | 19 (40) | 7 (21) | ||
| 2 | 4 (8) | 4 (12) | ||
| Diagnosis of ITP, n (%) | 0.087c | 0.768 | ||
| Before pregnancy | 38 (79) | 27 (82) | ||
| In pregnancy | 10 (21) | 6 (18) | ||
| pre-pregnancy platelet(× 109/L) | 38 (29.3, 73.8) | 45 (37, 64) | -1.491a | 0.136 |
| Platelet antibodies, n (%) | 0.320c | 0.572 | ||
| No | 8 (17) | 4 (12) | ||
| Yes | 40 (83) | 29 (88) | ||
| Obesity (BMI≧30) | NA | 0.393d | ||
| No | 46 (95.8) | 30 (90.9) | ||
| Yes | 2 (4.2) | 3 (9.1) | ||
| Diabetes | NA | 0.393d | ||
| No | 46 (95.8) | 30 (90.9) | ||
| Yes | 2 (4.2) | 3 (9.1) | ||
| Hypertension | NA | 0.393d | ||
| No | 46 (95.8) | 30 (90.9) | ||
| Yes | 2 (4.2) | 3 (9.1) | ||
| Medications, n (%) | NA | 0.683d | ||
| No | 45 (89.6) | 30 (90.9) | ||
| Yes | 3 (10.4) | 3 (9.1) | ||
| Baseline bleeding score, n (%) | 0.526c | 0.468 | ||
| 0 | 36 (75) | 27 (81.8) | ||
| 1 | 9 (18.8) | 1 (3) | ||
| 2 | 3 (6.3) | 5 (15.2) | ||
| Baseline blood values | ||||
| Platelets(× 109/L) | 18.6 ± 7.6 | 15 ± 8.9 | 1.970b | 0.052 |
| White cell count (× 109/L) | 6.6 (4.7, 10.8) | 7.3 (5.4, 11.5) | -0.745a | 0.456 |
| Neutrophil (%) | 65.9 (52.1, 77.9) | 71.7 (55.5, 78.5) | -0.971a | 0.332 |
| Lymphocyte (%) | 26.8 (15.9, 38.7) | 19.6 (14.6, 29.2) | -1.216a | 0.224 |
| Hemoglobin (g/L) | 105.5 (90, 116.8) | 107 (90.5, 115) | -0.125a | 0.901 |
| Hematocrit (%) | 31 (25.9, 33) | 31 (24, 35) | -0.644a | 0.519 |
| MPV (fL) | 12.5 ± 2.3 | 12 ± 2.1 | 0.963a | 0.338 |
| PDW (%) | 15 (13, 18.9) | 15.3 (14.6, 20.8) | -0.870a | 0.384 |
| P-LCR (%) | 38.9 ± 11.7 | 37.7 ± 9.2 | 0.478b | 0.634 |
| NLR | 0.7 (0.4, 1.4) | 0.6 (0.3, 1.2) | -1.447a | 0.148 |
| PLR | 11.4 (7, 15.5) | 9.2 (4.4, 17.6) | -1.043a | 0.297 |
| Prothrombin time (s) | 12.3 ± 0.8 | 12.2 ± 0.6 | 0.919b | 0.361 |
| Activated partial thromboplastin time(s) | 29.8 ± 3.6 | 31.3 ± 4.2 | -1.683b | 0.096 |
| Fibrinogen (g/L) | 4.2 ± 1.1 | 4.2 ± 1.1 | 0.076b | 0.940 |
| Dimer, μg/ml | 2.5 (1.4, 5.5) | 2.2 (1.4, 5.4) | -0.005a | 0.996 |
Abbreviations: BMI body mass index, NA not applicable, MPV mean platelet volume, PDW platelet distribution width, P-LCR platelet-large cell ratio, NLR neutrophil–lymphocyte ratio, PLR platelet-lymphocyte ratio
aMann-Whitney U Test
bIndependent-Samples Test
cChi-square test
dFisher exact probability test