Fig. 10.

Exosomes regulate lipid peroxidation levels in target cells through the miR-210/JAK1/STAT3 axis and improve mitochondrial function. A–J The effects of the miR-210/JAK1/STAT3 axis on lipid peroxidation and mitochondrial function were validated in vitro through a series of gain-of-function and loss-of-function experiments. Immunofluorescence detection and quantification of lipid peroxidation levels in Bend3 cells. Quantitative detection of MDA (Malondialdehyde, MDA) content in Bend3 cells. Representative images of mitochondrial morphology under confocal microscopy and quantification of mitochondrial length