Table 6. Skin absorption and toxicity assessment of natural products from AE O-NPV, NPV-P and AE NPV-P predicted by SwissADME and pkCSM server.

Compound name	Skin Permeability (log Kp≥−7.0 cm/s)	Toxicity
		AMES toxicity	Hepatotoxicity	Skin sensitization
Vanillic acid	−6.31	No	No	No
Catechin	−7.82	No	No	No
Quercetin	−7.05	No	No	No
Rutin	−10.26	No	No	No
Control inhibitors
Aloin	−8.94	No	No	No
Deoxyarbutin	−5.78	No	No	No
Arbutin	−8.92	No	No	No
Kojic acid	−7.62	No	No	No
Hexylresorcinol	−5.04	No	No	Yes