Figure 2. Cell-type specific lateral inhibition adjusts neural contrast sensitivity during perception A.

Average responses of V1 putative excitatory regular spiking (RS) neurons $(n=166)$ during contrast detection (sorted by contrast, right) in PV-ChR2 mice (4 mice, 26 sessions). Recordings at V1 retinotopic location of stimulus (Fig. 1B).

B. Same sessions and neurons as A during interleaved trials of distal PV stimulation, sorted by contrast.

C. Contrast response curve (mean ± SEM) during control (black) and PV stimulation (blue, gray-dashed line shows firing rate at lowest contrast). Response calculated during visual response window (first 0.2 s after stimulus in A and B).

D-F. Same as A-C, for SST-ChR2 mice (n = 146 RS neurons; 4 mice, 18 sessions).