Figure 2.

Macro-regions, micro-regions, and cell-to-cell distance.

A. The background defined based on a user-specified distance from the tumor boundary is removed from the whole-slide image. The remaining region of interest is partitioned into tumor region, tumor border, stroma border, and stroma region. B. Within the tumor region, there are small regions of interest, defined as micro-regions, which allow fine-grained analyses. C. The distance of a cell (e.g., a tumor cell) to another cell type (e.g., immune cells) is defined as the distance between the cell and its nearest neighbor of another cell type.