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[Preprint]. 2023 Nov 16:2023.11.15.567132. [Version 1] doi: 10.1101/2023.11.15.567132

Figure 1. Before SARS-CoV-2 exposure, PTM experienced uncontrolled SIV viremia and immunodeficiency due to loss of CD4+ T cells.

Figure 1.

A. Overall study design. Two female pigtail macaques (PTM, NV18 & NV19) were inoculated with SIVmac239 (100 TCID50, iv), followed by SARS-CoV-2 (Wa1/2020, 2X106, in/it) challenge approximately one year later. Figure created with BioRender (https://BioRender.com). B. Quantification of SIVmac239 RNA levels in plasma overtime (Quantitative RT PCR). C-E. CD4+ T cell kinetics following SIVmac239 infection in blood (C), bronchoalveolar lavage (BAL) (D), and gut (E).