Table 1.
Participant demographics at the time of stool sampling stratified by AD preclinical status.
| Healthy | Preclinical AD | P | ||
|---|---|---|---|---|
| Number | 115 | 49 | ||
| Age in years, mean (SD) | 77.02 (5.80) | 78.96 (4.51) | 0.039 | |
| Sex (%) | Male | 49 (42.6) | 24 (49.0) | 0.562 |
| Years of education, mean (SD) | 16.42 (2.26) | 16.69 (2.53) | 0.49 | |
| Race(%) | Black | 18 (15.7) | 1 (2.0) | 0.034 |
| White | 96 (83.5) | 48 (98.0) | ||
| Other | 1 (0.9) | 0 (0.0) | ||
| Body mass index, mean (SD) | 28.81 (5.03) | 26.73 (5.19) | 0.018 | |
| APOE4 (%) | e4+ | 26 (22.6) | 23 (46.9) | 0.003 |
| Active depression (%) | 3 (2.6) | 1 (2.0) | 1 | |
| Alcohol abuse (%) | 7 (6.1) | 1 (2.0) | 0.481 | |
| Autoimmune disorder† (%) | 11 (9.6) | 5 (10.2) | 1 | |
| Cancer(%) | 6 (5.2) | 2 (4.1) | 1 | |
| Cardiovascular disease (%) | 14 (12.2) | 6 (12.2) | 1 | |
| Diabetes (%) | 22 (19.1) | 1 (2.0) | 0.008 | |
| Hypercholesterolemia (%) | 69 (60.0) | 25 (51.0) | 0.373 | |
| Hypertension (%) | 74 (64.3) | 23 (46.9) | 0.057 | |
| Liver disease (%) | 7 (6.1) | 3 (6.1) | 1 | |
| Thyroid disease (%) | 21 (18.3) | 10 (20.4) | 0.917 | |
| Tobacco use (past or present) (%) | 51 (44.3) | 24 (49.0) | 0.709 |
P, Student’s t test (continuous variables) or chi-square test (categorical variables).
†
Rheumatoid arthritis, lupus, etc.