Table A1.
Description of cohort outcomes and demographics. Age data is missing from 36 patients in the UCLA: CRRT cohort. Age, sex, ethnicity, and race data is missing from 206 patients in the Cedars: CRRT cohort. Note that comorbidities are identified if the CCS codes described in Section 4.2 are recorded within 10 days before starting CRRT, which reflects the optimal window of the comprehensive model.
| UCLA CRRT | Cedars Sinai CRRT | UCLA Control | ||||||
|---|---|---|---|---|---|---|---|---|
| Overall | Do not recommend | Recommend | Overall | Do not recommend | Recommend | Do not recommend | ||
| n | 4161 | 1920 | 2241 | 3263 | 1462 | 1801 | 4725 | |
| Outcome, n (%) | ||||||||
| Comfort Care | 1179 (28.3) | 1179 (61.4) | - | 984 (30.2) | 984 (67.3) | - | - | |
| Expired | 741 (17.8) | 741 (38.6) | - | 478 (14.6) | 478 (32.7) | - | - | |
| Recovered renal function | 602 (14.5) | - | 602 (26.9) | 704 (21.6) | - | 704 (39.1) | - | |
| Transitioned to hemodialysis | 1639 (39.4) | - | 1639 (73.1) | 1097 (33.6) | - | 1097 (60.9) | - | |
| Total days on CRRT, median [Q1,Q3] | 6.0 [3.0,12.0] | 5.0 [2.0,12.0] | 6.0 [3.0,12.0] | 5.0 [3.0,10.0] | 4.0 [2.0,9.0] | 6.0 [4.0,11.0] | 0.0 [0.0,0.0] | |
| Year of CRRT, median [min,max] | 2018 [2015,2021] | 2018 [2015,2021] | 2018 [2015,2021] | 2019 [2016,2021] | 2019 [2016,2021] | 2019 [2016,2021] | 2018 [2005,2022] | |
| Number of previous CRRT Treatments, mean (SD) | 0.2 (0.7) | 0.1 (0.5) | 0.3 (0.8) | 0.2 (0.5) | 0.1 (0.4) | 0.2 (0.5) | 0.0 (0.0) | |
| Age, median [Q1,Q3] | 60.0 [47.0,69.0] | 60.0 [48.0,69.0] | 59.0 [45.0,68.0] | 66.0 [56.0,75.0] | 68.0 [58.0,78.0] | 63.0 [53.0,73.0] | 61.0 [49.0,70.0] | |
| Sex, n (%) | ||||||||
| Female | 1682 (40.4) | 765 (39.8) | 917 (40.9) | 1111 (36.3) | 537 (37.8) | 574 (35.0) | 1877 (39.7) | |
| Male | 2479 (59.6) | 1155 (60.2) | 1324 (59.1) | 1946 (63.7) | 882 (62.2) | 1064 (65.0) | 2848 (60.3) | |
| Ethnicity, n (%) | ||||||||
| Hispanic or Latino | 1416 (34.0) | 580 (30.2) | 836 (37.3) | 756 (24.7) | 307 (21.6) | 449 (27.4) | 1548 (32.8) | |
| Not Hispanic or Latino | 2745 (66.0) | 1340 (69.8) | 1405 (62.7) | 2301 (75.3) | 1112 (78.4) | 1189 (72.6) | 3177 (67.2) | |
| Race, n (%) | ||||||||
| American Indian or Alaska Native | 15 (0.4) | 11 (0.6) | 4 (0.2) | 4 (0.1) | 1 (0.1) | 3 (0.2) | 70 (1.5) | |
| Asian | 337 (8.1) | 163 (8.5) | 174 (7.8) | 249 (8.1) | 103 (7.3) | 146 (8.9) | 386 (8.2) | |
| Black or African American | 429 (10.3) | 199 (10.4) | 230 (10.3) | 462 (15.1) | 226 (15.9) | 236 (14.4) | 494 (10.5) | |
| Multiple Races | 42 (1.0) | 15 (0.8) | 27 (1.2) | 115 (3.8) | 40 (2.8) | 75 (4.6) | 58 (1.2) | |
| Native Hawaiian or Other Pacific Islander | 21 (0.5) | 10 (0.5) | 11 (0.5) | 12 (0.4) | 3 (0.2) | 9 (0.5) | 22 (0.5) | |
| Unknown | 1268 (30.5) | 555 (28.9) | 713 (31.8) | 500 (16.4) | 287 (20.2) | 213 (13.0) | 1499 (31.7) | |
| White or Caucasian | 2049 (49.2) | 967 (50.4) | 1082 (48.3) | 1715 (56.1) | 759 (53.5) | 956 (58.4) | 2196 (46.5) | |
| Heart comorbidities, n (%) | ||||||||
| No | 1798 (43.2) | 839 (43.7) | 959 (42.8) | 735 (22.5) | 246 (16.8) | 489 (27.2) | 3319 (70.2) | |
| Yes | 2363 (56.8) | 1081 (56.3) | 1282 (57.2) | 2528 (77.5) | 1216 (83.2) | 1312 (72.8) | 1406 (29.8) | |
| Liver comorbidities, n (%) | ||||||||
| No | 2271 (54.6) | 1046 (54.5) | 1225 (54.7) | 1536 (47.1) | 605 (41.4) | 931 (51.7) | 3624 (76.7) | |
| Yes | 1890 (45.4) | 874 (45.5) | 1016 (45.3) | 1727 (52.9) | 857 (58.6) | 870 (48.3) | 1101 (23.3) | |
| Infection comorbidities, n (%) | ||||||||
| No | 1878 (45.1) | 845 (44.0) | 1033 (46.1) | 1121 (34.4) | 376 (25.7) | 745 (41.4) | 3648 (77.2) | |
| Yes | 2283 (54.9) | 1075 (56.0) | 1208 (53.9) | 2142 (65.6) | 1086 (74.3) | 1056 (58.6) | 1077 (22.8) | |