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[Preprint]. 2023 Nov 16:rs.3.rs-3580132. [Version 1] doi: 10.21203/rs.3.rs-3580132/v1

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Anti-microbial peptide gene expression and proteins are significantly increased after cervicovaginal cell exposure to live bacteria or culture supernatants from G. vaginalis. RNA-seq identified CCL20, SLPI, LCN2 and S100A8 as being significantly upregulated by live G. vaginalis and its supernatants in ectocervical (A, B), endocervical (E, F) and vaginal (I, J) epithelial cells. ELISAs further identified that these anti-microbial peptides were increased after live G. vaginalis (C, G, K) or G. vaginalis culture supernatant exposure (D, H, J). Values are mean ± SEM. Asterisks over the individual bars represent comparisons to control; asterisks over solid lines represent comparisons between treatment groups. *p<0.05, **p<0.01, ***p<0.001, ****p<0.0001.