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[Preprint]. 2023 Nov 16:rs.3.rs-3580132. [Version 1] doi: 10.21203/rs.3.rs-3580132/v1

Figure 5.

Figure 5

Inflammasome activation by G. vaginalis is specific to the NLRP3 inflammasome. Pre-treatment with glybenclamide, a specific NLRP3 inhibitor, was able to partially reduce the G. vaginalis-mediated increases in caspase-1 (A, D, G) and IL-1β (B, E, H) with no changes to cell death. Values are mean ± SEM. Asterisks over the individual bars represent comparisons to non-treated control; asterisks over solid lines represent comparisons between treatment groups. *p<0.05, **p<0.01, ***p<0.001, ****p<0.0001.