Table 1:
Altered Inflammasome-related genes of interest after exposure to live L. crispatus or G. vaginalis
| Ectocervical | Endocervical | Vaginal | ||||
|---|---|---|---|---|---|---|
| Gene of Interest | LC | GV | LC | GV | LC | GV |
| NLRP3 associated genes | ||||||
| NLRP3 | 0.01 | 1.44 | 0.17 | 1.28 | 0.08 | 1.82 |
| NOD1 | 0.06 | 0.02 | 0.32 | 0.30 | −0.05 | −0.01 |
| NOD2 | −0.11 | 0.41 | 1.13 | 2.29 | −0.42 | 0.17 |
| NEK7 | −0.09 | 0.26 | −0.38 | −0.39 | 0.02 | 0.07 |
| NLRP1 associated genes | ||||||
| NLRP1 | 0.008 | 0.36 | 0.29 | 1.21 | 0.13 | 0.72 |
| Canonical Inflammasome genes | ||||||
| Caspase-1 | 0.15 | 0.29 | −0.17 | 0.79 | −0.31 | −0.59 |
| IL-1B | 0.16 | 0.96 | 0.31 | 2.06 | 0.15 | 1.37 |
| IL-18 | −0.01 | 0.41 | −0.22 | −0.46 | 0.16 | 0.10 |
| IL-1a | 0.12 | 1.29 | 0.30 | 2.07 | 0.23 | 1.12 |
Altered genes after exposure to live bacteria are shown as Log2FC from the non-treated control (NTC), gray shading denotes p≤0.01