Table 1:
Initial patient-level data collections in the Glioblastoma External Data Platform
| Source | |||||||||
|---|---|---|---|---|---|---|---|---|---|
|
|
|||||||||
| Total | Cho et al. 2011 (PMID: 22001862) | DFCI GBM | NCT00441142 | NCT00689221 | NCT00813943 | NCT00943826 # | NCT02977780 | UCLA/KP GBM | |
| n = 1,662 (%) | n = 16 (1) | n = 625 (38) | n = 27 (2) | n = 272 (16) | n = 88 (5) | n = 459 (28) | n = 69 (4) | n = 106 (6) | |
| Age | |||||||||
| Median (range) | 58 (17 – 94) | 58 (36 – 69) | 60 (17 – 94) | 55 (26 – 73) | 57 (21 – 78) | 57 (21 – 74) | 56 (18 – 79) | 59 (24 – 75) | 58 (20 – 79) |
| < 65 | 1,277 (77) | 12 (75) | 442 (71) | 25 (93) | 219 (81) | 77 (88) | 378 (82) | 54 (78) | 70 (66) |
| >= 65 | 385 (23) | 4 (25) | 183 (29) | 2 (7) | 53 (19) | 11 (12) | 81 (18) | 15 (22) | 36 (34) |
| Sex | |||||||||
| Female | 684 (41) | 8 (50) | 270 (43) | 12 (44) | 129 (47) | 34 (39) | 165 (36) | 28 (41) | 38 (36) |
| Male | 978 (59) | 8 (50) | 355 (57) | 15 (56) | 143 (53) | 54 (61) | 294 (64) | 41 (59) | 68 (64) |
| KPS | |||||||||
| <90 | 481 (29) | 7 (44) | 245 (39) | 5 (19) | 120 (44) | 49 (56) | - | 24 (35) | 31 (29) |
| 90–100 | 646 (39) | 9 (56) | 304 (49) | 22 (81) | 152 (56) | 39 (44) | - | 45 (65) | 75 (71) |
| Unknown | 535 (32) | - | 76 (12) | - | - | - | 459 (100) | - | - |
| RPA | |||||||||
| 3 | 234 (14) | 2 (12) | 65 (10) | - | 46 (17) | 16 (18) | 78 (17) | - | 27 (25) |
| 4–5 | 1,309 (79) | 14 (88) | 537 (86) | - | 226 (83) | 72 (82) | 381 (83) | - | 79 (75) |
| Unknown | 119 (7) | - | 23 (4) | 27 (100) | - | - | - | 69 (100) | - |
| MGMT promoter methylation status | |||||||||
| Unmethylated | 768 (46) | 7 (44) | 313 (50) | 15 (56) | - | 88 (100) | 236 (51) | 69 (100) | 40 (38) |
| Methylated | 687 (41) | 9 (56) | 254 (41) | 6 (22) | 272 (100) | - | 116 (25) | - | 30 (28) |
| Unknown | 207 (12) | - | 58 (9) | 6 (22) | - | - | 107 (23) | - | 36 (34) |
| Extent of Surgical Resection | |||||||||
| Biopsy | 130 (8) | - | 55 (9) | 5 (19) | - | - | 42 (9) | 6 (9) | 22 (21) |
| Gross total resection | 771 (46) | 11 (69) | 293 (47) | 9 (33) | 137 (50) | 46 (52) | 192 (42) | 37 (54) | 46 (43) |
| Subtotal resection | 746 (45) | 5 (31) | 277 (44) | 13 (48) | 126 (46) | 36 (41) | 225 (49) | 26 (38) | 38 (36) |
| Unknown | 15 (1) | - | - | - | 9 (3) | 6 (7) | - | - | - |
| IDH mutation status | |||||||||
| Wildtype | 760 (46) | - | 620 (99) | 17 (63) | - | - | - | 69 (100) | 54 (51) |
| Mutant | 6 (0) | - | 1 (0) | 4 (15) | - | - | - | - | 1 (1) |
| Unknown | 896 (54) | 16 (100) | 4 (1) | 6 (22) | 272 (100) | 88 (100) | 459 (100) | - | 51 (48) |
|
| |||||||||
| Time-to-event in months | |||||||||
| Follow-up time | |||||||||
| Median (95% CI) | 33 (32 – 35) | NR (NR - NR) | 55 (46 – 71) | 38 (22 - NR) | 30 (28 – 32) | 22 (21 - NR) | 31 (29 – 32) | 19 (15 – 23) | 40 (37 – 47) |
| Overall survival | |||||||||
| Median (95% CI) | 19 (19 – 20) | 14 (12 – 24) | 21 (20 – 22) | 16 (11 – 32) | 27 (24 – 33) | 14 (13 – 15) | 17 (15 – 18) | 15 (13 – 17) | 21 (19 – 26) |
| Progression-free survival | |||||||||
| Median (95% CI) | 9 (8 – 10) | 8 (7 – 18) | 10 (10 – 11) | 8 (5 – 23) | 15 (12 – 19) | 8 (6 – 8) | 6 (6 – 8) | 6 (6 – 8) | 8 (6 – 11) |
KPS = Karnofsky Performance Status
RPA = Recursive Partioning Analysis
MGMT = O6-methylguanine-DNA-methyltransferase
IDH = isocitrate dehydrogenase
#
Limited data access, used in prior analysis3