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. Author manuscript; available in PMC: 2024 Nov 1.
Published in final edited form as: Ann Neurol. 2023 Aug 31;94(5):987–1004. doi: 10.1002/ana.26758

Figure 4. Each GNAO1 variant presents a unique functional profile and can be placed on a spectrum of Loss-of-function/Dominant Negative activity.

Figure 4.

A. Meta-analysis of all GNAO1 variants, combining the results of all functional experiments.

B. Each variant can be placed on a spectrum with loss-of-function and dominant negative properties. Dots are colored according to mutation site as in panel A.