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. Author manuscript; available in PMC: 2023 Nov 27.
Published in final edited form as: J Am Chem Soc. 2019 Sep 3;141(36):14089–14092. doi: 10.1021/jacs.9b07294

Figure 2.

Figure 2.

Evaluation of MLMH vaccines. (A) Anti-METH antibody midpoint titers measured by ELISA using serum from vaccinated mice (n = 6/group) on days 21 (bleed 1) and 35 (bleed 2). Bars denote means ± SEM (B) (+)-METH-induced hyperlocomotor activity in vaccinated mice (n = 6/group) at 2 and 4 mg/kg. Bars denote means ± SEM *P < 0.05 determined by one-way ANOVA. (C) Concentration of (+)-METH in the blood and brains of vaccinated and naive mice (n = 6/group). Bars denote means ± SEM ***P < 0.001 determined by one-way ANOVA. (D) Kaplan−Meier curve for survival in vaccinated groups (n = 5 or 6/group). The efficacy of MH6-TT, an anti-METH vaccine previously reported by the Janda Laboratory, was evaluated and shown for comparison.