Table 2.

Pye-scanning Cyclic Hexapeptides Experimental Data

ID	log $D_{\text{dec}/\text{w}}$	$\text{LPE}$ a	P app b	solubilityc
1	2.0	3.5	8.1	16
1-Pye 2	1.3	4.1	1.7	640
1-Pye 3	−0.41	2.5	0.66	550
1-Pye 4	0.02	2.9	0.30	580
1-Pye 5	−0.42	2.5	0.32	510
1-Pye 6	−0.30	2.6	0.66	720
2	2.0	3.5	5.3	240
2-Pye 2	−0.29	2.6	0.56	610
2-Pye 3	−0.29	2.6	1.1	450
2-Pye 4	0.040	2.9	1.3	460
2-Pye 5	−0.82	2.0	0.13	550
2-Pye 6	−0.29	2.6	1.5	560
3	2.0	3.6	8.0	63
3-Pye 2	1.1	3.9	1.5	730
3-Pye 3	−0.22	2.7	0.23	140
3-Pye 4	0.21	3.1	0.14	580
3-Pye 5	0.14	3.0	0.28	550
3-Pye 6	0.16	3.0	0.18	600

^a$\text{LPE}$ = log $D_{\text{dec}/\text{w}}$ – 1.06 x $\text{ALogP}$ + 5.47⁵³; $\text{ALogP}$ = 3.74 for 1, 2 and 3; 2.46 for Pye-containing cyclic hexapeptides.

^bPAMPA x 10⁻⁶ cm/s, N=4.

^cμM, pH 7.4, N=3.