Table 3. Outcome measures of change in body mass and thyroid function between the two dietary interventions (n = 11).

Variable	KD	HCLF	Diet effect p value	Period effect p value
Change in body mass (kg)*	-2.9 (-3.5,-2.4)	-0.4 (-1.0, 0.1)	<0.0001	0.785
RMR (kcal.h-1.kg-1)##	1.16 (1.01, 1.31)	1.14 (0.98, 1.29)	0.122	0.031
Thyroid Stimulating Hormone (TSH, mIU/L)	2.06 (1.57,2.55)	2.32 (1.84,2.82)	0.071	0.042
Thyroxine (free T4, pmol.L-1)	19.3 (17.8, 20.9)	17.3 (15.7, 18.8)	0.0066	0.0004
Triiodothyronine (free T3, pmol.L-1)	4.1 (3.8, 4.4)	4.8 (4.5, 5.2)	<0.0001	0.0005
T3:T4 ratio	0.25 (0.12, 0.39)	0.41 (0.27, 0.55)	0.0467	0.0817

Data are presented as mean (95% CI)

All measures are within normal ranges: TSH (0.27–4.20 mIU/L), T4 (12.0–22.0 pmol/L), T3 (3.1–6.8 pmol/L)

KD, ketogenic diet; HCLF, high-carbohydrate low-fat diet

*change from either baseline or washout according to diet sequence

^##data from n = 9