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. Author manuscript; available in PMC: 2023 Nov 27.
Published in final edited form as: Hypertension. 2020 Sep 28;76(5):1526–1536. doi: 10.1161/HYPERTENSIONAHA.120.15829

Figure 1. Key clinical and proteomic correlates of plasma ACE2.

Figure 1.

Lower plasma ACE2 was associated with various clinical factors, including older age, male sex, diabetes mellitus, a lower estimated glomerular filtration rate, worse New York Heart Association (NYHA) class and higher pro-BNP levels, but were not associated with angiotensin-converting enzyme inhibitor (ACEI) and/or angiotensin-receptor blocker (ARB) use. In a broad proteome-wide association study, plasma ACE2 was associated with various canonical pathways, including clathrin-mediated endocytosis signaling, actin cytoskeleton signaling, mechanisms of viral exit from host cells, the protein ubiquitination pathway.