Table 3.

Association between serum aldosterone concentrations and CAC stratified by sex or age.

Estimates	Adjusted relative ratio [95% CI] *, †, ‡		P for interaction
	Male	Female
Total	1.23 [1.04–1.45]	1.00 [0.84–1.20]	0.06
PRA ≤ 0.5	1.67 [1.20–2.32]	1.21 [0.68–2.12]	0.002
PRA > 0.5	1.10 [0.90–1.35]	1.05 [0.82–1.34]	0.77
	Age ≤60 years	Age >60 years
Total	1.25 [1.04–1.51]	1.19 [1.00–1.42]	0.66
PRA ≤ 0.5	0.62 [0.36–1.04]	1.67 [1.15–2.43]	0.11
PRA > 0.5	1.38 [1.10–1.74]	1.08 [0.86–1.35]	0.21

CAC, coronary artery calcium score; CI, confidence interval.

^*Relative ratio of CAC at follow-up is calculated per 100 pg/ml increase in serum aldosterone concentrations.

^†Negative binomial regression model was employed to estimate relative ratio accounting for a right-skewed distribution of CAC.

^‡Adjusted for age, sex, CAC at exam 2 or 3, race, education, insurance status, income, smoking status, alcohol intake, physical activity, statin prescription, BMI, LDL, serum sodium, serum potassium, urinary sodium, urinary potassium, plasma renin activity, and time from aldosterone measurement to CAC follow-up.