Figure 3.

PPI Network of YP-SS: The interactive PPI network was constructed using data from the STRING database, with a minimum required interaction score set at 0.9. It includes a total of 206 nodes and 395 edges. Each node corresponds to relevant targets in this network, while the edges represent protein-protein associations. These associations encompass various types, such as known interactions (indicated by azure for curated databases and purple for experimentally determined interactions), predicted interactions (highlighted in green for gene neighborhood, red for gene fusions, and blue for gene co-occurrence), as well as other interactions (shown in light green for text mining, black for co-expression, and light blue for protein homology). (B) The core PPI network of core proteins is derived from (A); it consists of 36 nodes and 114 edges. (C) The C-D-T network for YP against SS consists of 91 nodes and 262 edges. In this network, red circles represent diseases, blue diamonds represent drugs, pink triangles indicate active drug ingredients, and yellow round rectangles signify target genes. (D) The top ten genes were selected based on degree value. PPI = protein-protein interaction, YP-SS = Yiqiyangyinquyu prescription-Sjögren’s syndrome.