(A) Continuous and categorical comparison of threshold-normalized DDIR score and status by HRD status within the S9313 TNBC cohort. For continuous comparison, P is Mann-Whitney; for categorical comparison, P is chi-square. (B) Continuous and categorial comparison of threshold normalized DDIR score and status by HRD status within the TCGA cohort. For continuous comparison P is Mann-Whitney; for categorical comparison P is chi-square. (C) Continuous and categorial comparison of threshold normalized DDIR score and status by tumor BRCA mutation status within the S9313 TNBC cohort. For continuous comparison P is Mann-Whitney; for categorical comparison P is chi-square. (D and E) Distribution of DDIR/HRD classes and threshold normalized DDIR and HRD scores within the (D) S9313 and (E) TCGA TNBC cohorts. r is Spearman's coefficient. DDIR, DNA damage immune response; HRD, homologous recombination deficiency; TCGA, The Cancer Genome Atlas; TNBC, triple-negative breast cancer.